An enzyme-catalysed access to amphiphilic triblock copolymer of PCL-b-PEG-b-PCL: synthesis, characterization and self-assembly properties

Preparation and in vivo pharmacokinetics of curcumin-loaded PCL-PEG-PCL triblock copolymeric nanoparticles

BACKGROUND Curcumin (CUR) has been linked with antioxidant, anti-inflammatory, antimicrobial, anti amyloid, and antitumor effects, but its application is limited because of its low aqueous solubility and poor oral bioavailability. METHODS To improve its bioavailability and water solubility, we synthesized two series of poly (ε-Caprolactone)-poly (ethylene glycol)-poly (ε-Caprolactone) tribloc...

Synthesis and Characterization of Nano-Hydroxyapatite/mPEG-b-PCL Composite Coating on Nitinol Alloy

In this study the bioactivity of hydroxyapatite/poly(ε-caprolactone)–poly(ethylene glycol) bilayer coatings on Nitinol superelastic alloy was investigated. The surface of Nitinol alloy was activated by a thermo-chemical treatment and hydroxyapatite coating was electrodeposited on the alloy, followed by applying the polymer coating. The surface morphology of coatings was studied using FE-SEM and...

preparation of hydrogels based on inclusion complexes of the triblock copolymer pcl-peg-pcl with α-cyclodextrin (α-cd)

Sequential crystallization and morphology of triple crystalline biodegradable PEO-b-PCL-b-PLLA triblock terpolymers

The sequential crystallization of poly(ethylene oxide)-b-poly(e-caprolactone)-b-poly(L-lactide) (PEO-b-PCL-b-PLLA) triblock terpolymers, in which the three blocks are able to crystallize separately and sequentially from the melt, is presented. Two terpolymers with identical PEO and PCL block lengths and two different PLLA block lengths were prepared, thus the effect of increasing PLLA content o...

Preparation and Characterization of PCL-PEG-PCL Copolymeric Nanoparticles as Polymersomes for Delivery Hydrophilic Drugs

Background: A novel drug delivery system using poly (ε-caprolactone) - poly (ethylene glycol) -poly (ε-caprolactone) (PCL-PEG-PCL) was established in this study. Methods: Ceftriaxone (CTX) was encapsulated within PCL-PEG-PCL nanoparticles by a double emulsion technique (w/o/w), leading to creation of ceftriaxone-loaded PCL-PEG-PCL (CTX/PCL-PEG-PCL) polymersomes. The resulting polymersomes...